Cisplatin hepatotoxicity
WebFeb 2, 2024 · There is substantial evidence that protective medications can alleviate drug-induced organ toxicity by modulating both Nrf2 and NF-κB signaling pathways. Thus, it has become increasingly important to explore the crosstalk mechanism between Nrf2 and NF-κB in drug-induced toxicity. WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe …
Cisplatin hepatotoxicity
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WebSep 15, 2024 · Cisplatin is mutagenic, teratogenic and carcinogenic and its use has been show to increase the risk of secondary malignancies, particularly leukemia. … WebPreventive Effect of Curcumin against Cisplatin-related Hepatotoxicity in Swiss Albino mice (Mus musculus L.) Jul 2024 - Jun 2024 …
WebMay 18, 2024 · Cisplatin is an anti-neoplastic agent for solid organ tumors has side effects on most organs including hepatotoxicity. 21, 22 In this study, we showed that CP can significantly induce hepatotoxicity in … WebCisplatin is one of the most potent cytotoxic anticancer medicines; nonetheless, hepatotoxicity and lymphotoxicity are two of its significant adverse effects, which …
WebAn association between cisplatin administration and hepatotoxicity is proposed in this patient. Conclusions: This patient may have experienced cisplatin-induced liver … Webabstract = "Generation of free radicals in the kidney cortex plays an important role in the pathogenesis of cisplatin-induced dysfunction of renal proximal tubule cells.
WebFeb 1, 2024 · Hesperidin plays an important role in the prevention of many diseases due to its anti-inflammatory, anti-oxidant, anti-ulcer, and anti-carcinogenic activities,2,3in addition to its anti-melanogenic and neuroprotective effects.4,5Moreover, it has anti-microbial, anti-allergic, immunomodulatory, hepatoprotective, and nephroprotective effects.6-8The …
WebCisplatin (cis-diamminedichloroplatinium, CDDP), one of the most widely used chemotherapeutic drugs for a variety of tumors, exhibits anticancer activity via formation of CDDP-DNA adducts. 6 However, its clinical use has been hampered by the intrinsic and adaptive resistances of the tumor cells along with severe toxic effects, which greatly … the physics of high brightness beamsWebDrug-induced liver injury (DILI) is the most common cause of acute liver failure worldwide. 1, 2 Cisplatin (CP) is one of the most common and potent anti-neoplastic agents used against testicular, ovarian, cervical, as well as bladder malignancies. 3 – 6 Despite its effectiveness, CP use is limited due to its serious toxic side effects such as … the physics of god pdfWebThe results suggest that the plant extract (250 and 500 mg/kg) was effective in significantly altering the indices of cisplatin induced dysfunction of renal proximal tubule cells under oxidative stress by decreasing the concentration of … sickness diarrhea farting burping bloatingWebDec 20, 2024 · Altered hepatic drug metabolism due to underlying liver disease can result in higher or more persistent drug levels, thereby causing increased systemic toxicity (particularly myelosuppression) or worsening of liver function because of … the physics of heaven by bill johnsonWebJul 22, 2024 · Cisplatin-induced kidney toxicity is reviewed here. The use of cisplatin in patients with pre-existing kidney dysfunction and the kidney effects of the platinum … sickness definition medical anthropologyWebMultivariate analysis showed that HIPEC regimen was the main risk factor of hepatotoxicity induced by HIPEC, with cisplatin + docetaxel being an independent risk factor of the HIPEC-induced hepatotoxicity. Open HIPEC techniques and HIPEC duration more than 60 minutes tend to increase the incidence of hepatotoxicity. sickness definition chartWebNational Center for Biotechnology Information sickness deduction